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. 2007 Jul 5;583(Pt 2):719–730. doi: 10.1113/jphysiol.2007.136838

Figure 5. Responsiveness of submucosal arterioles to sympathetic vasoconstrictors in normal and TNBS-inflamed colons.

Figure 5

A, superfusion of ATP caused large vasoconstrictions that rapidly desensitize in arterioles from control colons. TNBS colitis abolished the responsiveness of arterioles to ATP. B, summary data on constriction amplitude to ATP (control: n = 17; TNBS: n = 7) and phenylephrine (control: n = 9; TNBS: n = 12), an α-adrenoceptor agonist in control and TNBS colons. Colitis abolished constrictions to ATP whereas constrictions to phenylephrine were unaffected. *P < 0.01.