Table 6.

Body weight and adiposity in chow-fed genetically selected DIO and DR rats

Parameter	DR	DIO
Body weight (g)
Day 30, First measurement	64.2 ± 1.9	71.4 ± 1.5*
Day 37	109.2 ± 2.9	119.6 ± 2.2*
Day 47, Training onset	172.3 ± 3.2	194.7 ± 3.6***
Day 77, Baseline onset	295.1 ± 5.7	348.9 ± 7.2***
Day 79, Dose–response onset	301.8 ± 6.0	359.0 ± 7.7***
Day 111, Antagonist-reversal onset	355.3 ± 11.3	445.0 ± 11.1***
Day 121, Study completion	378.4 ± 7.4	456.4 ± 18.1**
Fat Pads
White fat pad (g)
Inguinal	8.02 ± 0.54	7.31 ± 0.54
Gonadal	6.77 ± 0.27	5.03 ± 0.27**
Retroperitoneal	3.96 ± 0.25	2.96 ± 0.25*
Mesenteric	5.15 ± 0.34	4.54 ± 0.34
Subcutaneous	1.95 ± 0.23	1.54 ± 0.23
Total	25.86 ± 1.35	21.37 ± 1.36†
Brown fat pad (g)	0.42 ± 0.06	0.58 ± 0.06
White fat pad (% body weight)
Inguinal	1.70 ± 0.11	1.91 ± 0.15
Gonadal	1.46 ± 0.05	1.35 ± 0.10
Retroperitoneal	0.79 ± 0.05	0.83 ± 0.09
Mesenteric	1.10 ± 0.05	1.19 ± 0.10
Subcutaneous	0.44 ± 0.03	0.39 ± 0.05
Total	5.49 ± 0.23	5.68 ± 0.45
Brown fat pad (% body weight)	0.11 ± 0.01	0.13 ± 0.01
Whole Carcass Adiposity
Fat (g)	37.64 ± 2.10	30.86 ± 2.10†
Fat (% body weight)	8.84 ± 0.44	9.21 ± 0.79

Body weight and adiposity in DIO and DR rats (n = 8–9/genotype through day 77, n = 9/genotype from day 111 to study completion). Absolute (g) fat pad and whole carcass fat (g) values reflect the estimated marginal means from ANCOVA in which body weight was a covariate. Percentage (%) fat pad and whole carcass percentage (%) fat values reflect the raw, uncorrected fat pad masses expressed as a percentage of body weight. Values are means ± s.e.m.

^*P < 0.05

^**P < 0.01

^***P < 0.001

^†P = 0.06 (Student's t test).