Table 1.

Effect of the treatment with 1 μg g⁻¹ of murine recombinant leptin for 3 days on the body weight of Y₁R/LacZ transgenic male or female mice fed with standard chow or with a MHF diet for 8 weeks

	Males weight (g)		Females weight (g)
Days of treatment	Chow-fed mice	MHF-fed mice	Chow-fed mice	MHF-fed mice
d0	22.69 ± 0.35	26.77 ± 0.44	21.74 ± 0.62	23.18 ± 0.91
d3	21.82 ± 0.45*	25.09 ± 0.74a	21.22 ± 0.56	22.68 ± 0.96

Data are the mean ±s.e.m. from 6 (chow-fed males), 8 (chow-fed females), 9 (MHF fed males) and 12 (MHF fed females) determinations. One-way ANOVA for repeated measurements: males, overall effect: F_1,13 = 30.06, P = 0.001; effect of leptin treatment, F_1,1 = 7.42, P = 0.017.

^*P < 0.01 versus chow-fed mice at d0

^aP = 0.053 versus MHF-fed mice at d0; females, overall effect: F_1,18 = 1.384, P = 0.25.