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. 2007 Jun 6;583(Pt 2):431–436. doi: 10.1113/jphysiol.2007.136051

Figure 1. New working model for regulation of activity in the HPA axis.

Figure 1

The schema on the left shows the standard GC-mediated feedback of HPA function on the brain as well as the fact that the GC act on peripheral energy stores. The schema on the right shows our current working model. Note that the effect of GC on brain is now excitatory, and that there is a signal from energy stores that now is inhibitory on the brain and HPA axis (GC, glucocorticoids; CNS, central nervous system; CRF, corticotropin-releasing factor; MA, monoamines; DA, dopamine).