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. 2007 Aug 9;584(Pt 1):59–73. doi: 10.1113/jphysiol.2007.136119

Figure 2. EC3 contribution to AE2 regulation by pHi and pHo.

Figure 2

A, schematic of constructs 10 (AE2–AE1EC3) and 11 (AE1–AE2EC3). B, regulation of 36Cl− efflux by pHi in (n) oocytes expressing the indicated AE polypeptides. C, normalized rate constants for the indicated AE polypeptides in (n) oocytes in the presence of butyrate (acidic pHi). Interchange of EC3 residues does not alter regulation by pHi. D, regulation of AE-mediated 36Cl− efflux at sequentially changing pHo values. E, pHo(50) values in (n) oocytes expressing the indicated AE polypeptides. Interchange of EC3 residues does not alter regulation by pHo.