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A, representative 36Cl− efflux traces from individual oocytes expressing the indicated AE polypeptides during sequential pHo transitions from 5.0 to 8.5, followed by exposure to the inhibitor, DIDS. B, normalized pHo dependence of 36Cl− efflux (right) by (n) oocytes expressing the indicated wildtype and chimeric AE2 polypeptides (numbered schematics and symbols at left).
