Figure 9. Effects of substance P on facial and C4 nerve activities in Atp1a2−/− mice.
A, C4 nerve activity during the second application of 100 nm substance P. A′, C4 nerve activity during the fifth application of substance P. B, facial and C4 nerve activities during the fourth application of 100 nm substance P in a different preparation. Substance P induced high-frequency bursts in both nerves. B′, averaged facial nerve activity triggered by C4 (10 cycles). Note that the facial nerve burst precedes the C4 inspiratory burst. C, increase of C4 burst rate in response to repeated application of 100 nm substance P for 10 min with 10 min intervals. Values are averaged from five preparations. VII, facial nerve activity; C4, C4 inspiratory activity.