Figure 2.

Integrative control of coronary vasomotor tone in dogs (lower panels) and swine (upper panels) at rest and during treadmill exercise Shown are the effects of adenosine receptor blockade with 8-phenyltheophylline (8PT; left panels), the effects of K_ATP channel blockade with glibenclamide (Glib) and additional adenosine receptor blockade (middle panels), and the effects of NO synthase inhibition with N-nitro-l-arginine (NLA) and additional adenosine receptor blockade and K_ATP channel blockade (right panels) on the relation between myocardial oxygen consumption (MVO₂) and coronary venous oxygen tension (CVPO₂) in the left ventricles. Data in dogs are from references (Bache et al. 1988 (left panel); Duncker et al. 1995 (centre panel); Ishibashi et al. 1998 (right panel)). Swine data are from Merkus et al. (2003a). Data are mean ±s.e.m.