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Murine gammaherpesvirus-68 (γHV68) infection exacerbates fluorescein isothiocyanate (FITC)–induced fibrosis in IL-4/13−/− mice. Wild-type and IL-4/13−/− mice were given FITC intratracheally on Day 0. On Day 14, FITC-treated mice received γHV68 (5 × 104 pfu; solid bar) or mock infection (stipled bar) intranasally. Lungs were harvested for collagen determination on Day 21. Data represent n = 6 mice per group. NS = not significant.
