Figure 3.

Skelatal muscle proteasome system A, the relative expressions of MuRF1, MAFbx and 20S proteasome mRNAs measured in soleus muscle of rats fed with either vehicle (hydroxypropylmethylcellulose) or GW610742 at 5 mg (kg bm)⁻¹ (cross-hatched columns) and 100 mg (kg bm)⁻¹ (open columns). The values are expressed as 2^−ΔΔC_t normalized to endogenous cyclophilin. The group of vehicle treated rats was used as calibrator with a value of 1. *Significantly different from the corresponding control (vehicle) group (P < 0.05). B, the 20S proteasome chymotrypsin-like enzymatic activity measured in soleus muscle of rats fed with either vehicle (hydroxypropylmethylcellulose) (filled columns) or GW610742 at 5 mg (kg bm)⁻¹ (cross-hatched columns) and 100 mg (kg bm)⁻¹ (open columns).