Table 1.
Muscle metabolite and DNA and alkaline soluble protein concentrations in rat soleus skeletal muscle after six days of gavage feeding of GW610742 at 5 (n = 8), and 100 mg (kg bm)−1 (n = 8) or with a 0.1% vehicle solution (hydroxypropylmethylcellulose; n = 8)
| Vehicle | 5 mg kg−1 | 100 mg kg−1 | |
|---|---|---|---|
| ATP (mmol (kg DM)−1) | 18.08 ± 1.03 | 19.62 ± 1.14 | 19.59 ± 0.44 |
| PCr (mmol (kg DM)−1) | 55.31 ± 2.57 | 57.22 ± 3.58 | 63.60 ± 1.31 |
| Creatine (mmol (kg DM)−1) | 45.86 ± 2.66 | 43.00 ± 3.39 | 41.11 ± 1.88 |
| Total creatine (mmol (kg DM)−1) | 101.2 ± 3.9 | 100.2 ± 3.7 | 104.7 ± 2.2 |
| Lactate (mmol (kg DM)−1) | 0.70 ± 0.05 | 0.76 ± 0.09 | 0.87 ± 0.11 |
| Acetylcarnitine (mmol (kg DM)−1) | 0.93 ± 0.05 | 0.97 ± 0.03 | 0.92 ± 0.09 |
| DNA (g (kg DM)−1) | 4.17 ± 0.48 | 4.73 ± 0.43 | 4.16 ± 0.26 |
| Protein (g (kg DM)−1) | 449.1 ± 32.5 | 497.4 ± 18.4 | 481.1 ± 13.2 |
| DNA/protein | 115.5 ± 18.1 | 108.2 ± 11.6 | 116.7 ± 4.3 |
Values expressed as means ±s.e.m. (n = 8). DM, dry muscle.