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. Author manuscript; available in PMC: 2008 Mar 31.
Published in final edited form as: Biol Psychiatry. 2007 Sep 24;63(4):353–359. doi: 10.1016/j.biopsych.2007.07.016

Fig. 3.

Fig. 3

ADT and CORT chronically regulated pERK1/2 in dentate gyrus and dorsal striatum. (a) Prior CORT exposure suppressed ERK1/2 phosphorylation in the dentate gyrus, consistent with evidence from targets both upstream and downstream and with behavioral consequences of CORT. As with PR responding and immobility, subsequent AMI reversed the deficit. (b) In the dorsal striatum, a main effect of CORT exposure and a CORTxAMI interaction effect were observed. Post-hoc comparisons revealed a selective down-regulation of pERK1/2 in CORT-exposed animals subsequently treated with AMI. Analysis of pERK1 alone revealed the same effect (not shown). Bars represent means (±SEM) per treatment group (**p≤0.001, *p≤0.05, †p=0.08). Representative blots are displayed in the same order as the experimental groups in the plots above. “C+AMI” refers to the CORT+AMI group.