Table 1.
Baseline Variables by Treatment Groupa
| All Randomized Participants |
||||||
|---|---|---|---|---|---|---|
| SSRI (n = 168) | Venlafaxine (n = 166) | P Value | No CBT (n = 168) | CBT (n = 166) | P Value | |
| Demographic characteristics | ||||||
| Age, mean (SD), ya | 16.0 (1.6) | 15.8 (1.5) | .22 | 15.8 (1.6) | 16.0 (1.5) | .25 |
| White race/ethnicity, No. (%)a | 138 (82.1) | 139 (83.7) | .70 | 136 (81.0) | 141 (84.9) | .33 |
| Female sex, No. (%)a | 121 (72.0) | 112 (67.5) | .37 | 117 (69.6) | 116 (69.9) | .96 |
| Income, median (range), thousands $ | 60 (8–500) | 62 (0–250) | .84 | 62.5 (8–500) | 59 (0–190) | .58 |
| College graduatea | 80 (50.6) | 72 (45.0) | .32 | 76 (47.2) | 76 (48.4) | .83 |
| Clinical characteristics | ||||||
| Children’s Depression Rating Scale-Revised mean (SD)a,b | 59.9 (10.6) | 57.8 (10.1) | .07 | 58.4 (9.7) | 59.2 (11.0) | .50 |
| Clinical Global Impressions-Severity, mean (SD)a | 4.5 (0.6) | 4.4 (0.7) | .77 | 4.5 (0.6) | 4.5 (0.7) | .91 |
| Children’s Global Assessment Scale, mean (SD)a | 50.3 (7.8) | 50.9 (7.6) | .46 | 50.6 (7.7) | 50.6 (7.7) | >.99 |
| Beck Depression Inventorya,c | 21.9 (12.0) | 19.1 (12.0) | .03 | 19.6 (11.5) | 21.4 (12.6) | .17 |
| Suicidal Ideation Questionnairea | 42.8 (22.0) | 40.4 (22.6) | .31 | 41.9 (21.1) | 41.3 (23.5) | .81 |
| Children’s Depression Rating Scale-Revised % change between assessments, median (interquartile range) | 6.9 (25.4) | 5.3 (21.4) | .77 | 4.9 (24.2) | 6.8 (23.0) | .47 |
| Comorbidity, No. (%) | ||||||
| Anxiety (including posttraumatic stress disorder)a | 59 (36.4) | 60 (36.4) | .99 | 60 (35.9) | 59 (36.9) | .86 |
| Posttraumatic stress disorderd | 17 (10.1) | 7 (4.2) | .04 | 15 (8.9) | 9 (5.5) | .22 |
| Attention-deficit/hyperactivity disordera | 26 (15.8) | 26 (15.7) | .98 | 23 (13.8) | 29 (17.7) | .33 |
| Oppositional/conduct | 15 (9.0) | 18 (11.0) | .56 | 18 (10.8) | 15 (9.2) | .63 |
| Dysthymiaa | 45 (27.1) | 53 (32.1) | .32 | 51 (30.5) | 47 (28.7) | .71 |
| Clinical history | ||||||
| First episode of depression, (No. %)a | 122 (74.8) | 119 (73.0) | .71 | 122 (73.5) | 119 (74.4) | .86 |
| Duration current major depressive disorder episode, mean (SD), moa | 23.5 (21.6) | 21.4 (19.0) | .36 | 22.6 (21.4) | 22.3 (19.4) | .88 |
| Age at onset of major depressive disorder symptoms, mean (SD), ya | 12.6 (2.6) | 12.8 (2.4) | .45 | 12.5 (2.6) | 12.9 (2.4) | .20 |
| History of suicide attempts, No. (%)a | 45 (26.9) | 34 (20.5) | .17 | 44 (26.3) | 35 (21.1) | .26 |
| Concomitant treatment at intake, No. (%) | ||||||
| Anxiety medication | 1 (0.6) | 3 (1.8) | .31 | 2 (1.2) | 2 (1.2) | >.99 |
| Sleep medicationa | 12 (7.1) | 8 (4.8) | .37 | 11 (6.5) | 9 (5.4) | .67 |
| Stimulant medicationa | 13 (7.7) | 20 (12.0) | .19 | 20 (11.9) | 13 (7.8) | .21 |
Abbreviations: CBT, cognitive behavioral therapy; SSRI, selective serotonin reuptake inhibitor.
a
Different statistical significance among sites.
b
Statistical measures: t = 1.84; P = .07.
c
Statistical measures: t = 2.17; P = .03.
d
Statistical measures: ; P = .04.