Figure 6.
LexA-modifying inhibition of WT/PKA cleavage. Representative cleavage reactions of 0.5 μM WT/PKA, K156A, and RecA are shown. Samples were pre-incubated at 30°C for 1 h before starting reactions by adding RecA (Reaction #1, open circles) or WT/PKA (Reaction #2, closed squares). Selected portions of the data (4.5-25 min for Reaction 1, and 0-6 min for Reaction 2) were fit to straight lines that correspond to rates of 0.008 and 0.022 LexA/RecA/min for Reactions 1 and 2 respectively. The solid line represents the expected kinetics of Reaction 2, based on the cleavage rate of Reaction 1 (see text).