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. Author manuscript; available in PMC: 2009 Mar 20.
Published in final edited form as: Int J Pharm. 2007 Oct 12;352(1-2):17–28. doi: 10.1016/j.ijpharm.2007.10.003

Scheme 2.

Scheme 2

The ionization and binding equilibra considered in the data analyses. I, II and III refer to the DB-67 lactone, DB-67 carboxylate monoanion and dianion, respectively. Their corresponding membrane/water partition coefficients are represented by KI, KIII and KIV. The equilibrium constants Ka and Ka2 refer to the ionization of the E-ring lactone and A-ring hydroxyl groups, respectively, and the subscripts and superscripts m and w refer to the intravesicular and extravesicular compartments.