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. 2008 Mar 20;6:5. doi: 10.1186/1740-3391-6-5

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Copyright © 2008 van der Veen et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Activity patterns and genotypes. A) Double plotted actogram of a wildtype mouse (left panel) and a Per1^m/mPer2^m/mdouble-mutant mouse (right panel) during a period of light-dark 12:12 followed by a free running rhythms in continuous dim red light. B) Genotyping example of four animals used in this study. Using the same primer sets, lane 1 and 3 show the lighter PCR products for the Per1 and the Per2 fragments indicating the Per1^m/mPer2^m/mdouble-mutant genotype in both mice, lane 2 and 4 show the heavier PCR products for both genes indicating the Per1^+/+Per2^+/+genotype in both mice. Molecular weight scales are in kiloDalton.