Table 1.
Genes differentially expressed in Networks A and B.
| Network | IPA Score* | Increased in CIN III | Decreased in CIN III |
| A | 22 | BH3 interacting domain death agonist | cyclin-dependent kinase inhibitor 2B |
| cytochrome b-561 | Cbp/p300-interacting transactivator, with | ||
| dihydrofolate reductase | Glu/Asp-rich carboxy-terminal domain, 2 | ||
| nuclear receptor co-repressor 1 | endothelin 3 | ||
| sialidase 1 | interferon-related developmental regulator 1 | ||
| peptidyl-prolyl cis/trans isomerase, NIMA- | Kruppel-like factor 6 | ||
| interacting | phosphatase and tensin homolog RAB4A | ||
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | retinoblastoma-like 2 (p130) | ||
| B | 17 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | adaptor-related protein complex 3, mu 2 subunit |
| B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | cyclin-dependent kinase inhibitor 2B cellular repressor of E1A-stimulated genes 1 | ||
| creatine kinase, brain | Kruppel-like factor 6 | ||
| mortality factor 4 like 2 | keratin 17 | ||
| Mof4 family associated protein 1 | tropomodulin 3 | ||
| ribophorin I | |||
| stomatin (EPB72)-like 2 | |||
* The score is a numerical value used to rank networks according to how relevant they are to the genes in your input dataset. Calculations are based on the hypergeometric distribution calculated via the computationally efficient Fisher's Exact Test for 2 × 2 contingency tables8. Gene symbols in bold denote those selected for validation in a new panel of fourteen cases.