Table 1. DC-SIGN+-dendritic cells are present in the sub-epithelial tissues of the respiratory tract.
Tissues | CD150# | DC-SIGN | Co-localization | n | ||
Upper respiratory tract | Buccal cavity | Epithelium | 0 | 0 | 0 | 1 |
Sub-epithelium | + | +++ | 0/+ | |||
Pharynx | Epithelium | + | 0 | 0 | 1 | |
Sub-epithelium | + | +++ | 0 | |||
Tonsillar crypt | Epithelium | 0/+ | 0 | 0 | 2 | |
Sub-epithelium | + | +++ | 0 | |||
Lower respiratory tract | Trachea | Epithelium | 0 | 0 | 0 | 2 |
Sub-epithelium | 0/+ | ++ | 0 | |||
Bronchus | Epithelium | 0 | 0 | 0 | 2 | |
Sub-epithelium | 0 | ++ | 0 | |||
Lung | Interstitium | 0/+ | 0/+ | 0 | 2 | |
Lymphoid tissue | Tonsil | Folicle | +++ | +++ | ++ | 3 |
Inter-folicular | +++ | +++ | ++ | |||
Lymph node | B-cell area | +++ | + | + | 1 | |
T-cell area | +++ | ++ | ++ | |||
Medullary sinus | +++ | +++ | +++ |
The number of DC-SIGN+- or CD150+- cells was determined by counting the number of positive cells, divided by the total number of cells, based on the nuclei staining. The double-positive cells were divided by the total number of stained cells, to determine the co-localization. 0 = 0–1%, + = 1–5%, ++ = 5–25%, +++ = 25–100% of the cells, n = number of donors analyzed per tissue.