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. Author manuscript; available in PMC: 2009 Jan 14.
Published in final edited form as: Eur J Pharmacol. 2007 Oct 2;578(2-3):349–358. doi: 10.1016/j.ejphar.2007.09.029

Figure 2.

Figure 2

Effects of the α1-adrenoceptor antagonists prazosin (Praz) and HEAT on phenylephrine (PE) stimulated ERK1/2 in submandibular gland slices or SMG-C10 cells. Slices or cells were incubated with 100 nM of an antagonist for 30 min followed by addition of 10 μM PE for 7 min. Data are plotted as % of 10 μM PE stimulated ERK1/2 in the absence of antagonist (Control). (A) Bar graph of data using submandibular gland slices, showing significant inhibition of PE stimulated ERK1/2 to basal levels by the α1-adrenoceptor antagonists Praz and HEAT. (B) Bar graph of data using SMG-C10 cells, showing significant inhibition by Praz and HEAT of PE stimulation of ERK1/2. All data are the means ± S.E.M. of 4-5 individual experiments, each using submandibular gland slices taken from a different animal or using different SMG-C10 cell cultures. *Significantly different from Control (10 μM PE alone), p < 0.05.