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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Nucl Med Biol. 2007 Nov 19;35(1):43–52. doi: 10.1016/j.nucmedbio.2007.08.007

Table 1.

Inhibition constants (Ki) of NET ligands binding to homogenates prepared from LLC cells respectively expressing norepinephrine, serotonin and dopamine transporters

Compound LLC-NET (nM) LLC-SERT (nM) LLC-DAT (nM)
8 5.3 ± 0.3 >5,000 >10,000
9 4.5 ± 0.7 >1,500 >10,000
10 32.5 ± 5.0 >2,000 >10,000
11 13.5 ± 2.5 >1,000 >30,000
nisoxetine 4.8 ± 1.7 >2000 >15,000

Studies were carried out with 0.08-0.08 nM [125I]INXT for NET, 0.1-0.2 nM [125I]IDAM for SERT and 0.1-0.2 nM [125I]IPT for DAT. Values are the mean ± SEM of three determinations performed in duplicate.