Table 1.

Basal systolic blood pressure and renal functional indexes in Agtr1a+/+, Agtr1a+/−, and Agtr1a−/− mice

Parameters	Agtr1a+/+	Agtr1a+/−	Agtr1a−/−
Body wt, g	26.9±1	28.2±0.8	27.5±1.1
Kidney wt, g	0.32±0.02	0.34±0.01	0.27±0.02a
Kidney-to-body wt ratio, X100	1.2±0.03	1.2±0.01	1.0±0.04a
Drinking, ml/24 h	4.2±0.2	4.9±0.4	7.2±0.8a
SBP, mmHg	112±2	104±3a	88±2a,c
UNaV, μmol/24 h	133.0±7.1	156.4±8.5b	334.7±7.8a,c
UKV, μmol/24 h	257.8±22.5	313.6±23.3b	648.8±8.5a,c

Values are means ± SE. Agtr1a+/+, wild-type mice; Agtr1a+/−, heterozygous mice; Agtr1a−/−, homozygous mice; SBP, systolic blood pressure; U_NaV, urinary sodium excretion; U_KV, urinary potassium excretion.

^bP < 0.05 or

^aP < 0.01 vs. Agtr1a+/+; and

^cP < 0.01 vs. Agtr1a+/−.