Table 2.

SBP, drinking and renal excretory responses to ANG II infusion alone or concurrent administration of ANG II and the AT₁ receptor antagonist losartan during the 1st week in wild-type, Agtr1a+/−, and Agtr1a−/− mice

	Wild-type			Agtr1a+/−			Agtr1a−/−
Responses	C	ANG II	ANG II+L	C	ANG II	ANG II+L	C	ANG II	ANG II+L
SBP, mmHg	113±4	153±7b	132±4b,d	104±3	145±4b	135±2b,c	89±5f	99±4f	95±3f
Drinking, ml/24 h	2.6±0.3	4.3±0.6a	2.9±0.2	5.2±0.2	5.5±0.4	4.4±0.4	9.3±0.7f	8.0±0.8f	7.6±0.5f
UNaV, μmol/24 h	158±6.8	150±5.9	184±7.8	235±4.6	229±9.5	263±4.1	236±9.4f	252±14f	186±9.9
UKV, μmol/24 h	397±18.1	263±10.5a	435±14.8a	539±5.6	354±24.7b	553±11.3d	527±19.3e	479±25f	426±16.7

Results are expressed as means ± SE. C, control or basal; L, losartan. The differences in the same response between different groups for the same strain of mice were analyzed by one-way ANOVA:

^aP < 0.05 or

^bP < 0.01 vs. control;

^cP < 0.05 or

^dP < 0.01 vs. ANG II. The differences in the same response between wild-type or Agtr1a+/− and Agtr1a−/− mice were analyzed by unpaired t-test:

^eP < 0.05 or

^fP < 0.01 versus wild-type or Agtr1a+/− mice.