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. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2007 Sep 21;13(11):1294–1303. doi: 10.1016/j.bbmt.2007.07.014

FIGURE 3. Sema4D −/− Tcell recipients have improved survival and clinical GVHD scores.

FIGURE 3

(a-f) BALB/c (allogeneic) or B6 (syngeneic) recipients were lethally irradiated (800cGy) and intravenously given 5.0×106 B6 wt BM and either 5.0×105 wt B6 or Sema4D −/− T cells. (a-c) On day +14 mice were humanely euthanized and (a) spleens of recipient animals were analyzed for total H2b CD3+ Tcells (b) serum IFNγ levels (c) CD4+ and CD8+ donor derived (H2b) chimerism. (d) survival (e) % weight loss and (f) GVHD scores compared to d+0. (d-f) B6 (solid line), Sema4D −/− Tcells (dashed line) and BALB/c (dotted line). # p<0.01 *p<0.05 **p<0.02 ***p<0.06. Results are representative of one of three similar experiments with a total of n =18 / allogeneic recipients of the control and sema4−/− donors.