. Author manuscript; available in PMC: 2008 Nov 1.

Published in final edited form as: Biol Blood Marrow Transplant. 2007 Sep 21;13(11):1294–1303. doi: 10.1016/j.bbmt.2007.07.014

TABLE 1. Anti-Sema4D monoclonal antibody effects in allogeneic responses.

BALB/c stimulators and either BALB/c or wtB6 T cells +/− anti-Sema4D monoclonal antibody (1μg/mL). BALB/c splenocytes irradiated and co-cultured with T cells at a 2/1 stimulator/responder ratio. Non-irradiated CD11c+ BALB/c DCs and either BALB/c T cells or B6 wt T cells +/− anti-Sema4D mAbs at a 2:1 ratio where co-cultured for the analysis of TNFα and IL-12p70. Cytokine levels measured from supernatants 18-24 hours later.

	SYN	WT (allo control)	WT (anti-Sema4DmAbs)
cpm	824+/− 445	10614+/−900	7229+/−808^*
IL-12p70	275+/−60	377+/−54	233+/−39
TNFα	50+/−40	654+/−57	326+/−29^*

P<0.03