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. Author manuscript; available in PMC: 2008 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2007 Sep 8;17(22):6206–6211. doi: 10.1016/j.bmcl.2007.09.023

Scheme 2.

Scheme 2

Reagents and conditions: (a): MeSNa, THF, RT; (b): HI 57%, RT; (c): MeZnCl, Pd(PPh3)4, THF, RT to 60°C; (d): 4-trifluoromethylbenzeneboronic acid, Na2CO3, Pd(PPh3)4, EtOH, Toluene, water, 110°C; (e): mCPBA, DCM, RT; (f): cyclohexylamine, DMF, 150°C, microwaves, 20 min.