Table 2.
Cpd | R | 2.5 µM of Cpd, 1 µM of GABA | 25 µM of Cpd, 1 µM of GABA | 1 µM of GABA | |
---|---|---|---|---|---|
Effect (%) ± sem | Effect (%) ± sem | pEC50 ± sem | Emax (%) ± sem | ||
22 | 80 ±1 | 93 ± 5 | 6.06 ± 0.05 | 83 ± 4 | |
25 | 90 ± 1 | 80 ± 2 | 5.56 ± 0.13 | 132 ± 14 | |
26 | 125 ± 4 | 141 ± 6 | 5.46 ± 0.10 | 185 ± 15 | |
27 | 122 ± 3 | 110 ± 0 | 5.78 ± .03 | 183 ± 4 | |
28 | 82 ± 5 | 52 ± 4 | - | - | |
29 | 128 ± 4 | 70 ± 4 | 5.78 ± 0.03 | 137 ± 3 | |
30 | 28 ± 1 | 32 ± 2 | - | - | |
31 | 36 ± 2 | 69 ± 6 | - | - | |
32 | 29 ± 1 | 39 ± 2 | - | - | |
33 | 40 ± 3 | 21 ± 7 | - | - | |
34 | 58 ± 11 | 59 ± 4 | - | - |