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. Author manuscript; available in PMC: 2009 Mar 1.
Published in final edited form as: Peptides. 2007 Nov 21;29(3):440–447. doi: 10.1016/j.peptides.2007.11.005

Figure 1. Effects of ICV [D-Trp8]-γ-MSH Infusion in Experiment 1.

Figure 1

(A). Food Intake: On day 1, there was a decline in food intake characteristic of the animals’ response to ketamine/xylazine anesthesia in both the [D-Trp8]-γ-MSH and the saline control groups. On day 2, a trend toward greater food intake among [D-Trp8]-γ-MSH rats vs. saline controls was noted but this was not significant (n = 8/group; p = 0.24). (B & C). Hypothalamic Pomc and Agrp Expression (expressed as pg/100 pg Cyc): Pomc mRNA levels were significantly decreased in [D-Trp8]-γ-MSH animals compared to controls (*p = 0.012); Agrp mRNA levels tended to be lower in the [D-Trp8]-γ-MSH group but this was not significant (p = 0.1).