Figure 4. Effects of ICV Low Dose PG-932 Infusion.
(A) Body Weight: Rats treated with PG-932 at a dose of 0.5 ng/hr demonstrated significant weight loss (−5.8 ± 1.1 g; *p < 0.05, n = 6) compared to saline (−0.5 ± 2.0 g; n = 6) as well as to rats infused with PG-932 at 2.0 ng/hr (1.2 ± 2.0 g; n = 7) (p < 0.05). (B) Food Intake: A significant decline in food intake in the rats treated with the 0.5 ng/hr dose compared to the 2.0 ng/hr dose was noted 24 hours after infusion (*p < 0.05) as well as a tendency towards decreased food intake compared to saline controls (p = 0.07).