TABLE 1.
Selected QTL from the SM × NZB F2 cross for three complex traits
Trait | QTL | Chr | LOD | Nearest marker | High allele | Mode of inheritance | Mb peak (C.I. start–end) |
---|---|---|---|---|---|---|---|
HDL | Hdlq20 | 1 | 10.6 | D1Mit291 | NZB | Dom | 174 (168–184) |
Hdlq1 | 5 | 10.6 | D5Mit161 | NZB | Add | 122 (116–132) | |
Hdlq24 | 6 | 6.4 | D6Mit259 | NZB | Add | 128 (115–144) | |
Gallstone presence | Lith17 | 5 | 7.1 | D5Mit24 | SM | Add | 102 (88–122) |
Lith19 | 8 | 5.6 | D8Mit155 | SM | Rec | 6 (0–16) | |
Lith21 | 10 | 5.7 | D10Mit214 | NZB | Rec | 48 (18–58) | |
QTL for obesity and body weight | Obwq4 | 17 | 6.8 | D17Mit20 | NZB | Add | 54 (34–62) |
Obwq5 | 19 | 9.3 | D19Mit71 | NZB | Rec | 56 (48–60) | |
Obwq3 | 6 | 5.8 | D6Mit105 | SM | Rec | 100 (88–122) |
LOD scores are given with sex as an additive covariate except for the body weight and obesity phenotypes. Mb indicates millions of base pairs from the centromere (Build 36). Dom, dominant; Add, additive; Rec, recessive; C.I., 95% confidence interval.