Figure 1.—

Outline of signaling pathways affecting tubulogenesis. Canonical pathway components are indicated in black. Details of Drosophila homologs are indicated in blue. Genes identified in this study are indicated in red. The ETS domain is a DNA-binding domain that specifically interacts with sequences containing the common core trinucleotide GGA and is involved in protein–protein interactions with cofactors that help determine its biological activity. RBPs, receptor binding proteins; ROS, reactive oxygen species.