Fig. 2.

Progressive reduction of T lymphocytes in secondary lymphoid organs and blood lymphopenia in elderly TPPII KO mice. (A) Relative numbers of spleen lymphocyte subsets (n = 11 and n = 6 pairs of WT and KO littermates for young and old mice, respectively). (B) Increased proportions in memory CD8 T cells, which are CD44^high, in spleen and liver of KO and WT mice (n = 9 pairs of mice). Dot plots show the percentage of CD8⁺ cells in total splenocytes on the right of each frame and that of CD44^high cells in CD8⁺ cells in the upper right corner. (C) Strong reduction in WBC and lymphocyte counts in the blood of elderly KO mice (n = 16 KO and 14 WT mice).