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Effect of liposome composition on inhibitory potency of ibuprofen against COX-1 and -2. The apparent Ki value (K') for ibuprofen was determined for PGHS-1 (15 nM; left panel) and PGHS-2 (30 nM; right panel) in the presence of the indicated total phospholipid concentrations of DOPC, DOPC/DOPS or DOPC/DOPS/OA liposomes. The data were analyzed as described for the experiment in Table 2. The K' values plotted represent the averages ± SD for 2−4 independent experiments.
