Figure 5. Effect of cyclic guanylyl cyclase inhibitors on ATP-induced relaxation of Ang II-precontracted glomeruli.

Glomeruli were preincubated with 50 μM methylene blue (MB), 10 μM ODQ or PBS (Con) for 20 min and with 1 μM Ang II for a further 5 min. Incubation was continued with 1 μM ATP (filled bars) or PBS (open bars) for 2 min. Results are expressed as a percentage of basal value. Columns indicate means ±s.e.m. (n = 5%); *P < 0.05 ATP vs. PBS.