Table 1.
Group | PTot | Po | Prest | n2 | pCa50 | ΔpCa50 |
---|---|---|---|---|---|---|
(mN mm-2) | (mN mm-2) | (mN mm-2) | ||||
Control (7) | 25.8 ± 1.8 | 24.7 ± 1.7 | 0.8 ± 0.3 | 4.72 ± 0.38 | 5.85 ± 0.05 | |
6 μM NEM-S1 (7) | 23.7 ± 2.1 | 19.7 ± 1.6* | 3.7 ± 0.8* | 1.54 ± 0.07* | 5.95 ± 0.04* | 0.11 ± 0.02 |
All values are expressed as means ± S.E.M., with the number of ventricular preparations given in parentheses. PTot, maximal total tension (maximal Ca2+-activated tension plus Ca2+-independent tension); Po, maximal Ca2+-activated tension; Prest, Ca2+-independent tension at pCa 9.0; n2, Hill coefficient for Ca2+-activated force below 0.50 Po; pCa50, pCa required for half-maximal activation; ΔpCa50, change in pCa50 following addition of 6 μM NEM-S1.
*Significantly different from control (P < 0.05).