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. 2001 Jan 15;530(Pt 2):263–272. doi: 10.1111/j.1469-7793.2001.0263l.x

Table 1.

Steady-state mechanical measurements in skinned left ventricular myocardium in the absence and presence of 6 μM NEM-S1

Group PTot Po Prest n2 pCa50 ΔpCa50
(mN mm-2) (mN mm-2) (mN mm-2)
Control (7) 25.8 ± 1.8 24.7 ± 1.7 0.8 ± 0.3 4.72 ± 0.38 5.85 ± 0.05
6 μM NEM-S1 (7) 23.7 ± 2.1 19.7 ± 1.6* 3.7 ± 0.8* 1.54 ± 0.07* 5.95 ± 0.04* 0.11 ± 0.02

All values are expressed as means ± S.E.M., with the number of ventricular preparations given in parentheses. PTot, maximal total tension (maximal Ca2+-activated tension plus Ca2+-independent tension); Po, maximal Ca2+-activated tension; Prest, Ca2+-independent tension at pCa 9.0; n2, Hill coefficient for Ca2+-activated force below 0.50 Po; pCa50, pCa required for half-maximal activation; ΔpCa50, change in pCa50 following addition of 6 μM NEM-S1.

*Significantly different from control (P < 0.05).