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In the rats with intact vagus nerves, intraduodenal infusion of 10−5m 5-HT (unit 37) (A) and 10−4m 5-HT (unit 14) (B) increased the discharge frequency in a dose-dependent manner. C, following administration of granisetron, the same unit shown in A failed to respond to intraduodenal infusion of 5-HT. D, acute vagotomy abolished responses to intraduodenal infusion of 5-HT in the same unit shown in B.
