Figure 7. The diacylglycerol analogue OAG activates non-selective cation channels with similar characteristics to those of the spontaneous and noradrenaline-activated cation channels.

A shows that application of 10 μM OAG activates single cation channels (ii) in an outside-out patch which previously did not contain any spontaneous events (i). B, from the same patch the current-voltage relationship had a slope conductance of 23 pS and a reversal potential of +10 mV. The open time (C) and burst duration (D) distributions were similar to those for spontaneous and noradrenaline-evoked cation channels.