Table 3.
Absolute changes in haemodynamics during noradrenaline infusion
| Norad (ng kg−1 min−1) | HR (beats min−1) | PMAP (mmHg) | PPP (mmHg) | CI (l min−1 m−2) | PVR (a.u.) | CMAP (mmHg) | CPP (mmHg) | PPP:CPP ratio | AIx (%) | TR (ms) | P1-CDBP (mmHg) | ED (ms) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10 | −2 ± 2 | −1 ± 1 | 1 ± 1 | −0.1 ± 0.1 | 0.4 ± 0.7 | −1 ± 1 | 1 ± 1 | −0.01 ± 0.03 | 3 ± 2 | −4 ± 4 | 1 ± 1 | 1 ± 1 |
| 30 | −2 ± 2 | 5 ± 1 | 1 ± 2 | −0.1 ± 0.1 | 3.2 ± 0.7 | 5 ± 1 | 3 ± 1 | −0.09 ± 0.04 | 4 ± 2 | −1 ± 4 | 1 ± 1 | 8 ± 2 |
| 60 | −5 ± 2 | 13 ± 3 | 6 ± 2 | −0.1 ± 0.1 | 6.9 ± 2.2 | 13 ± 3 | 8 ± 2 | −0.19 ± 0.05 | 14 ± 2 | −11 ± 4 | 2 ± 1 | 11 ± 2 |
| 100 | −5 ± 4 | 19 ± 4 | 12 ± 3 | −0.1 ± 0.2 | 8.2 ± 2.4 | 19 ± 4 | 15 ± 3 | −0.27 ± 0.05 | 19 ± 1 | −16 ± 4 | 6 ± 2 | 9 ± 3 |
| P | 0.002 | < 0.001 | < 0.001 | 0.4 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | 0.001 | 0.029 | 0.1 |
Norad, noradrenaline; for rest of abbreviations see legend to Table 2. Data are presented as changes from baseline (means ±s.e.m.). Significance was determined using ANOVA compared with the placebo phase, n = 8.