Figure 3. Rhythmic activity recorded from the stomachs of wild-type and W/W^V mutant mice in the presence of nifedipine and caffeine.

Slow waves recorded from the circular muscle layer of the antral region of wild-type mice (A) persisted in the presence of nifedipine (10 μm; B) but were reduced in amplitude and duration following the addition of caffeine (1 mm) to the physiological saline (C). Rhythmical depolarizations recorded from the gastric antrum of W/W^V mutant mice (D) were also unaffected by 10 μm nifedipine (E). The waves of depolarization were similar in amplitude following the application of caffeine and their duration was also shortened (F). Note that the waves of depolarization (F) were similar in shape to those recorded from wild-type mice in the same solution (C). The time and voltage calibration bars apply to all recordings.