Figure 3. Inhibition of albumin uptake when microtubules are disrupted.

In the presence of nocodazole (33 μmol l⁻¹), when microtubules are disrupted and the transition from early endosomes (EE) to late endosomes (LE) is slowed down dramatically, EIPA still inhibited endocytosis, whereas H⁺-ATPase inhibition with bafilomycin A₁ (1 μmol l⁻¹) was virtually without effect. n = 6-9 for each value plotted. *P < 0.05 vs. control; **P < 0.05 vs. nocodazole.