Figure 6. L-type channel inhibition is insensitive to conditioning pre-pulses.
Low-Po channel activity recorded during pairs of test depolarizations at +10 mV before and after a sequentially applied pre-pulse (+150 mV, 280 ms) in the presence of opioidergic and purinergic agonists in the pipette solution (Vh -40 mV). The corresponding mean currents calculated from 249 sweeps pooled from 14 patches are shown below. The bottom traces are averaged currents at +10 mV calculated from 169 sweeps pooled from 10 patches in the presence of naloxone and suramin. Notice the larger amplitude of the currents under these conditions and the absence of any pre-pulse-induced facilitation.