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. 2001 Apr 1;532(Pt 1):73–90. doi: 10.1111/j.1469-7793.2001.0073g.x

Figure 11. Conditioning pre-pulses do not facilitate cAMP-potentiated L-channels.

Figure 11

L-channel activity recorded before and after a conditioning pre-pulse (+150 mV, 280 ms) in control patches pre-incubated with 1 mm 8-CPT-cAMP for 30 min. Repolarisations to -80 mV lasted 40 ms. Most traces displayed high-Po activity before the conditioning pulse. Pre-pulses were ineffective in either accelerating the activation kinetics or increasing the Po of L-channels. The mean currents below were calculated over 55 sweeps pooled from 10 patches. The bottom traces were obtained from 37 sweeps pooled from 4 patches pre-incubated with 8-CPT-cAMP and with the agonists in the pipette.