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. 2001 Apr 1;532(Pt 1):181–194. doi: 10.1111/j.1469-7793.2001.0181g.x

Figure 6. NMDA currents evoked by exogenously applied agonist.

Figure 6

A, the current required to hold an SCN neuron at -40 mV was plotted as a function of time. Increasing doses of bath-applied NMDA (10, 30 and 100 μm, indicated by open horizontal bars) elicited inward currents of increasing magnitude. A final dose of 100 μm NMDA was applied during a prolonged period of d-AP5 superfusion (50 μm; indicated by hatched bar), revealing a specific action of the agonist at the NMDA receptor. This neuron was recorded during the subjective day. B, EPSC evoked by optic nerve stimulation in the same neuron, held at a potential of -30 mV. The EPSC contained a minor prolonged component indicative of low NMDA receptor activity. Dotted line indicates baseline current.