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. 2001 Apr 15;532(Pt 2):399–409. doi: 10.1111/j.1469-7793.2001.0399f.x

Figure 4. cGMP sensitivity is modulated by PKC activity.

Figure 4

A, I-Vm relations obtained from a cell after treatment with 0.5 μm of the inactive isomer 4α-PMA. Ligand sensitivity of channels was similar to that of untreated control. B, I-Vm relations obtained from a cell after treatment with 0.5 μm PMA in the presence of 1 μm staurosporin. No modulation of channel activity was observed. C, comparison of channel sensitivity of control cells (dotted line, taken from Fig. 3C), cells treated with 4α-PMA (○, continuous line), cells treated with PMA in the presence of staurosporin (•, dashed line), and cells treated with PMA (dash-dotted line, taken from Fig. 3C).