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A, action potentials recorded from myocytes isolated from the epicardial (Epi), endocardial (Endo) and M regions of the canine left ventricle. B, transient outward current (Ito) recorded from the three cell types during depolarizing steps from a holding potential of -80 mV to test potentials ranging between -20 and +70 mV. Modified from Antzelevitch et al. (1999), with permission.
