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. 2001 May 15;533(Pt 1):91–97. doi: 10.1111/j.1469-7793.2001.0091b.x

Figure 1. Effects of NT-3 on conduction velocity of and EPSP amplitude elicited by axotomized group Ia afferent fibres.

Figure 1

Top panel, schematic diagram of experiments carried out in adult cats. Osmotic minipump containing NT-3 placed on axotomized medial gastrocnemius (MG) nerve affected axotomized MG sensory and motor axons. Response to stimulation of axotomized, treated MG afferents was examined in intact lateral gastrocnemius-soleus (LGS) motoneurones. Response of axotomized MG motoneurones to intact LGS afferents also measured. Bottom panel, treated afferents; intact motoneurones. Each symbol represents mean EPSP amplitude (ordinate) and afferent conduction velocity of large muscle afferent fibres (as % of value in intact nerve) from a single experiment. Numbers represent days after axotomy. In controls (open symbols: vehicle applied to nerve or neurotrophin administered systemically) conduction velocity and EPSP amplitude fell gradually after axotomy. After NT-3 (filled symbols), EPSP amplitude increased and conduction velocity recovered to 100 % after initial decline. * Mean values in unoperated cats. Dashed line indicates mean value of EPSP amplitude in intact cats. Data from Mendell et al. (1999).