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. 2001 Jun 15;533(Pt 3):717–728. doi: 10.1111/j.1469-7793.2001.t01-1-00717.x

Figure 8. The effects of ATP, kainate and GABA on Iheat.

Figure 8

ATP (A), kainate (B) and GABA (C) at 100 μm were superfused as indicated by the bars. A, control Iheat induced by a ramp of increasing temperature to 48 °C. ATP (100 μm) induced a fast desensitizing membrane current. The first heat ramp was applied when most of the initial ATP-induced current desensitized. The interval between the records in ATP is 20 s. The wash response was recorded 40 s after removing ATP. B, 100 μm kainate induced a fast inactivating membrane current. Heat ramps to 48 °C were applied at 20 s intervals. The wash response was recorded after 30 s. C, 100 μm GABA induced a desensitizing current. Note the increase of the rate of desensitization when the temperature of the heat ramp increased (arrow). In the noxious range, Iheat was similar to that in the control. GABA was applied continuously for 40 s when Iheat was recorded. Membrane potential clamped at −70 mV in all records.