A, MCA Vmean (middle cerebral artery mean blood velocity) during prolonged exercise in control (^), during hyperthermia (•) and in the when the values were ‘corrected’ and related to the Pa,CO2 in the control trial (▴). B, Pa,CO2 (calculated arterial carbon dioxide pressure) in control (^) and during hyperthermia (•). C, ventilation in control (^) and during hyperthermia (•). Values are means ±s.e.m. for 8 subjects. * Significantly different from 10 min value, P < 0.05; † significally different from control, P < 0.05.