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. 2001 Jul 1;534(Pt 1):1–14. doi: 10.1111/j.1469-7793.2001.t01-3-00001.x

Figure 9. Inactivation kinetics of double-deletion mutants.

Figure 9

A, family of current traces recorded from WT HERG, HERGNΔ12CΔ236, HERGNΔ12CΔ278, HERGNΔ354CΔ236, HERGNΔ354CΔ278, HERGNΔ12 and HERGNΔ354 are shown. Inactivation pulse protocol consisted of a pulse to +60 mV for 5 s with a subsequent pulse to −80 mV and a range of depolarizing potentials from +60 to −20 mV. B, inactivation time constants of WT HERG, HERGNΔ12CΔ236, HERGNΔ12CΔ278, HERGNΔ354CΔ236, HERGNΔ354CΔ278, HERGNΔ12 and HERGNΔ354 were plotted against test voltage (n = 20, P = 0.0004). Symbols are defined in the figure. Inactivation was slower in deletion mutants than in WT channels.