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A, time course of changes in integrated inspiratory burst amplitude (mean ±s.e.m.) following 30 s applications of 0.01, 0.1 and 1.0 μm SPNK1 over the XII nucleus (agonist applied starting at time t = 0; n = 9). B, dose-dependent effects of SPNK1 on inspiratory XII nerve burst amplitude (n = 9).
