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. 2001 Jul 15;534(Pt 2):465–478. doi: 10.1111/j.1469-7793.2001.00465.x

Figure 9. Effects of UK14,304 applied to various chambers on the amplitudes of ascending and descending reflex responses recorded in circular muscle.

Figure 9

Responses were recorded in the three-chambered organ bath at one end of the preparation and distensions applied either to the adjacent chamber (Near) or to the more distant one (Far). A, effect of the drug applied to the near chamber on excitatory reflexes (EJPs) evoked in it (near distension) or conducted through it (far distension) (n = 4 in both cases). B, effects of UK14,304 when applied to the whole bath on EJPs elicited by distension in the near chamber (n = 9). C, effects of UK14,304 applied to the recording chamber on EJPs (n = 5 for both near and far chamber distensions). D, effect of UK14,304 when applied to the near chamber on descending reflexes evoked in the near and far chambers (n = 5 in both cases). E, effect of UK14,304, when applied to the recording chamber, on descending reflexes (n = 5 in both cases). F, effect of UK14,304 when applied to the whole bath on IJPs, (near chamber distension, n = 6; far chamber distension, n = 5). Symbols indicate a significant difference from control, *P < 0.03, †P < 0.001.